2-Chlorobenzylamine → HCID 43445075、化合物

HRID 2105763ノート

反応式

HRID 2105763 の反応式
[N:1](=[C:3]([C:9]([CH3:11])=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5])O.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16]>C(#N)C>[CH2:7]([O:6][C:4]([C:3]1[N:1]=[C:15]([C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[Cl:12])[NH:16][C:9]=1[CH3:11])=[O:5])[CH3:8]

参加物

4

反応物 2

HCID 666482-ChlorobenzylamineHCID 178472877HCID 178472877、化合物

生成物 1

HCID 43445075HCID 43445075、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 8.5 g of ethyl 2-oximinoacetoacetate in acetonitrile (100 ml) was added 7.5 ml of 2-chlorobenzylamine. The reaction mixture was then refluxed for 4 hours under argon atmosphere. After such time the reaction mixture was then concentrated in vacuo and the residue was triturated with warm ethylacetate for 10 minutes. After allowing to cool down to room temperature the solid was filtered and dried in vacuo to yield 11.3 g of a white powder, MS (ISP) 265.1 (M+H)+.

後処理

  1. temperatureThe reaction mixture was then refluxed for 4 hours under argon atmosphere
  2. concentrationAfter such time the reaction mixture was then concentrated in vacuo
  3. customthe residue was triturated with warm ethylacetate for 10 minutes
  4. filtrationwas filtered
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-25a2a09442fc43d4ac61274d6ebc6a4e
出典データセット
uspto-grants-2009_08
特許番号
US07579369B2

反応ノート

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