Chloroacetyl chloride → N-methoxy-N-methyl-2-piperazin-1-yl-acetamide

反応式

C(O[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:16](Cl)=[O:17].[CH3:19][O:20][NH:21][CH3:22]>>[CH3:19][O:20][N:21]([CH3:22])[C:16](=[O:17])[CH2:6][N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

参加物

反応物 3

HCID 6577Chloroacetyl chloride

HCID 14232N,O-Dimethylhydroxylamine

HCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 57809253N-methoxy-N-methyl-2-piperazin-1-yl-acetamide

実験手順

The title compound was prepared from 1-tert-butyloxycarbonyl-piperazine, chloroacetylchloride and N-methoxy-N-methylamine in an analogous manner as described in example 21.

出典と根拠

ORDレコード: ord-454bc75ae56a44cb9aa871131ba39e28
出典データセット: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07579368B2

反応ノート

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