Sodium Hydroxide → 1,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one

HRID 2106055ノート

反応式

HRID 2106055 の反応式
C(OP([C:9]([F:26])([F:25])[C:10](=[O:24])[CH2:11][C:12]([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13])(=O)OCC)C.[OH-].[Na+]>CO.O>[F:26][CH:9]([F:25])[C:10](=[O:24])[CH2:11][C:12]([CH3:13])([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])[CH3:14]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 57809801[1,1-Difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester

生成物 1

HCID 578099691,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one収率 95.9%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of [1,1-difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester (1.0 g) in methanol (12.0 mL) was added a solution of sodium hydroxide (0.04 g) in water (1 mL). The mixture was stirred at room temperature for 30 minutes. The mixture was diluted with hexanes (50 mL) and water (50 mL) and the organic phase was separated, dried, filtered, and evaporated in vacuo to give 1,1,-difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one (0.63 g) as an oil which was used without additional purification.

後処理

  1. customthe organic phase was separated
  2. customdried
  3. filtrationfiltered
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-0044ed8a235c45e4b1ac87f2acfb4a03
出典データセット
uspto-grants-2009_08
特許番号
US07579469B2

反応ノート

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