Methanol → Propanoic acid, 2-((1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)oxy)-, ethyl ester

HRID 2106580ノート

反応式

HRID 2106580 の反応式
[Na].CO.[Cl:4][C:5]1[CH:6]=[C:7]([N:11]2[C:15]([CH3:16])=[N:14][C:13]([OH:17])=[N:12]2)[CH:8]=[CH:9][CH:10]=1.Br[CH:19]([CH3:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21]>CS(C)=O>[Cl:4][C:5]1[CH:6]=[C:7]([N:11]2[C:15]([CH3:16])=[N:14][C:13]([O:17][CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:25])=[N:12]2)[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 4

HCID 887MethanolHCID 79040Ethyl 2-bromopropionateHCID 5360545SodiumHCID 178433515HCID 178433515、化合物

生成物 1

HCID 163821Propanoic acid, 2-((1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)oxy)-, ethyl ester収率 68%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The process was carried out as was Example 9 above, starting with 0.8 g of sodium, 20 ml of methanol, 75 ml of dimethylsulfoxide, 7.8 g of 1-(3-chlorophenyl)-3-hydroxy-5-methyl-1,2,4-1H-triazole and 6.7 g of ethyl 2-bromopropionate. The yield was 7.8 g of the desired product, an oil.

出典と根拠

ORDレコード
ord-7bdb0280f5674c1ca46931c397fad17e
出典データセット
uspto-grants-1990_06
特許番号
US04931083

反応ノート

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