Ethyl Bromide → 3-ethyl-1-(4-nitrophenyl)-2,4(1H,3H)-pyrimidinedione

HRID 2106764

反応式

HRID 2106764 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]2=[O:17])=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[K+].Br[CH2:21][CH3:22]>CN(C)C(=O)C>[CH2:21]([N:12]1[C:13](=[O:16])[CH:14]=[CH:15][N:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[C:11]1=[O:17])[CH3:22]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 14797Potassium HydroxideHCID 112763381-(4-Nitrophenyl)pyrimidine-2,4-dione

生成物 1

HCID 151254793-ethyl-1-(4-nitrophenyl)-2,4(1H,3H)-pyrimidinedione収率 65.6%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A mixture of 3 parts of 1-(4-nitrophenyl)-2,4(1H,3H)-pyrimidinedione, 1,4 parts of potassium hydroxide and 67.5 parts of N,N-dimethylacetamide was stirred for 1 hour at room temperature under nitrogen atmosphere. 1.52 Parts of bromoethane were added and stirring was continued overnight at room temperature. The reaction mixture was poured into 100 parts of ice water. The product was filtered off and stirred in methanol. The product was filtered off and dried in vacuo at 60° C., yielding 2.4 parts (65.6%) of 3-ethyl-1-(4-nitro-phenyl)-2,4(1H,3H)-pyrimidinedione; mp. 182.5° C. (int. 24).

後処理

  1. stirringstirring
  2. waitwas continued overnight at room temperature
  3. filtrationThe product was filtered off
  4. stirringstirred in methanol
  5. filtrationThe product was filtered off
  6. customdried in vacuo at 60° C.

出典と根拠

ORDレコード
ord-d072a9a384e947f2a9bfee02dda21a87
出典データセット
uspto-grants-1990_06
特許番号
US04931444

関連ノート

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