Chlorine → 3,7-Dichloro-6-methoxy-1-benzothiophene-2-carbonyl chloride
反応式
[Cl:1]Cl.[Cl:3][C:4]1[C:5]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][C:6]=2[S:7][C:8]=1[C:9]([Cl:11])=[O:10]>C(Cl)(Cl)Cl>[Cl:3][C:4]1[C:5]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([Cl:1])[C:6]=2[S:7][C:8]=1[C:9]([Cl:11])=[O:10]参加物
4
実験手順
Chlorine (24 g) is bubbled into a stirred suspension of 3-chloro-6-methoxy-benzo[b]thiophene-2-carbonyl chloride (9.2 g, 35 mmoles) in chloroform (200 mls) over a period of 30 minutes. After an additional 45 minutes of stirring at room temperature the mixture is stripped of volatiles under reduced pressure. The residue is recrystallized from tetrahydrofuran (100 mls) to afford the pure product (6.6 g): mp=174°-175° C.
後処理
- customThe residue is recrystallized from tetrahydrofuran (100 mls)
出典と根拠
- ORDレコード
- ord-350407ca98714b2895de3103c918f34c
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04931459
反応ノート
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