Triethylamine → Ethyl (2-amino-2-methylpropyl)carbamate

HRID 2107564ノート

反応式

HRID 2107564 の反応式
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].C(N(CC)CC)C.Cl[C:15]([O:17][CH2:18][CH3:19])=[O:16]>CCOCC>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][C:15]([O:17][CH2:18][CH3:19])=[O:16]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 131282-Methylpropylenediamine

生成物 1

HCID 14722925Ethyl (2-amino-2-methylpropyl)carbamate収率 95%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
25 °C

実験手順

To a mixture of 88.2 g (1 mol) of 1,2-diamino-2-methylpropane, 50 ml of triethylamine and 500 ml of diethyl ether was added dropwise to a solution of 27.1 g (0.25 mol) of ethyl chloroformate in 100 mL of ether. The reaction mixture was stirred for 16 hours at 25° C. and filtered. Evaporation of the filtrate to dryness gave 38 g (95%) of product which was identified by NMR and IR spectroscopy.

後処理

  1. filtrationfiltered
  2. customEvaporation of the filtrate to dryness

出典と根拠

ORDレコード
ord-7897d64ac8fc4cd08d3b730f79faec83
出典データセット
uspto-grants-1990_06
特許番号
US04935421

反応ノート

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