Hydrochloric Acid → Diethyl 3-hydroxy-2-(2-methylpropyl)pentanedioate

HRID 2108275

反応式

HRID 2108275 の反応式
[BH4-].[Na+].[CH3:3][CH:4]([CH3:20])[CH2:5][CH:6]([C:12](=[O:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]([O:9][CH2:10][CH3:11])=[O:8].Cl>C(O)C.O>[OH:19][CH:12]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:6]([CH2:5][CH:4]([CH3:3])[CH3:20])[C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 99926592-Isobutyl-3-ketoglutarate diethyl ester

生成物 1

HCID 10377906Diethyl 3-hydroxy-2-(2-methylpropyl)pentanedioate収率 100%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Sodium borohydride (1.1 g, 29 mmol) was added to an ice-cold solution of diethyl 2-(2-methylpropyl)-3-oxopentanedioate (7.5 g, 29 mmol) in ethanol (75 ml). The mixture was stirred at 5°-10° C. for 2 h, then 2N hydrochloric acid (18 ml) was added slowly at 0° C., and the mixture was stirred at room temperature for 45 min. The mixture was diluted with water (400 ml), then was extracted with ethyl acetate (4×100 ml). The extracts were washed with water (2 100 ml) and brine (100 ml), then were dried (Na2SO4) and evaporated in vacuo to leave the title compound as an oil (7.5 g, 100%).

後処理

  1. stirringthe mixture was stirred at room temperature for 45 min
  2. extractionwas extracted with ethyl acetate (4×100 ml)
  3. washThe extracts were washed with water (2 100 ml) and brine (100 ml)
  4. dry with materialwere dried (Na2SO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-cca397e3f088445fac691e9687fc6b8f
出典データセット
uspto-grants-1990_06
特許番号
US04937243

関連ノート

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