HCID 69056186、化合物 → 3-(4-methylphenyl)-1H-indazole

HRID 2108995ノート

反応式

HRID 2108995 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=3[NH:10][N:9]=2)=[CH:4][CH:3]=1>C1[C@H]2[C@@H](CCCC2)CCC1.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 69056186HCID 69056186、化合物

生成物 1

HCID 98777323-(4-methylphenyl)-1H-indazole収率 82%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 178420442HCID 178420442、化合物溶媒

実験手順

Into the solution of compound 8 (12.3 g, 0.058 mol) in trans-decahydronaphthalene (trans-decalin) was added 10% Pd/C (2.7 g), and the mixture was heated under reflux for 4 h, and then concentrated in vacuo in oil bath until there were about 20 mL solution left. Petroleum ether (80 mL) was added into the residue while hot, and the mixture was well mixed by shaking. The mixture was allowed to precipitate upon cooling to afford 3-(4-methylphenyl)-1H-indazole (10, 9.85 g, 82% yield).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated in vacuo in oil bath until there
  4. waitleft
  5. additionPetroleum ether (80 mL) was added into the residue while hot, and the mixture
  6. additionwas well mixed
  7. customto precipitate
  8. temperatureupon cooling

出典と根拠

ORDレコード
ord-93a2cf5479a94d28888e08144c378f28
出典データセット
uspto-grants-2009_04
特許番号
US07514465B2

反応ノート

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