2-(Tributylstannyl)furan → 7-Amino-4-(furan-2-yl)isoindolinone

HRID 21092ノート

反応式

HRID 21092 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5](Br)=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2.C([Sn](CCCC)(CCCC)[C:18]1[O:19][CH:20]=[CH:21][CH:22]=1)CCC>C1COCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[C:6]2[C:10]=1[C:9](=[O:11])[NH:8][CH2:7]2

参加物

5

反応物 2

HCID 43936882-(Tributylstannyl)furanHCID 197019327-Amino-4-bromo-2,3-dihydroisoindol-1-one

生成物 1

HCID 684927397-Amino-4-(furan-2-yl)isoindolinone収率 55%

試薬・触媒・溶媒 2

HCID 178418476HCID 178418476、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (234 mg, 1.03 mmol) was dissolved in THF (11.6 mL), and the solution was treated with 2-(tributylstannyl)furane (0.649 mL, 2.06 mmol) and bis(triphenylphosphine)dichloropalladium (58 mg, 0.082 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetone=4/1, chloroform/methanol=12/1) to obtain 7-amino-4-(furan-2-yl)isoindolinone (121 mg, yield 55%).

後処理

  1. customfollowed by purification by preparative thin-layer chromatography (chloroform/acetone=4/1, chloroform/methanol=12/1)

出典と根拠

ORDレコード
ord-68c7b12d71e149028aac55c12e0e9711
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

反応ノート

読み込み中…