4-Bromophenol → HCID 23062453、化合物

HRID 2109374

反応式

HRID 2109374 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[C:14]([CH3:20])[C:11]=1[CH2:12]Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:20][C:14]1[C:15]([CH3:19])=[CH:16][C:17]([CH3:18])=[C:10]([CH3:9])[C:11]=1[CH2:12][O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1

参加物

5

反応物 3

HCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 819393-(Chloromethyl)-1,2,4,5-tetramethylbenzene

生成物 1

HCID 23062453HCID 23062453、化合物収率 79%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

In acetone (50 ml), a mixture of 4-bromophenol (7.8 g), 2,3,5,6-tetramethylbenzyl chloride (6.3 g) and potassium carbonate (6.5 g) was heated at reflux for 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and successively washed with 3% aqueous sodium hydroxide solution, water and saturated brine. The solvent was evaporated under reduced pressure, thereby giving 8.7 g of the desired compound.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationThe reaction solution was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in ethyl acetate
  6. washsuccessively washed with 3% aqueous sodium hydroxide solution, water and saturated brine
  7. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-52c09326b92d4d6db679987c70e3e86c
出典データセット
uspto-grants-2009_04
特許番号
US07514452B2

関連ノート

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