Tetrabutylammonium Fluoride → 2-(4-Bromofuran-2-yl)pyridine

HRID 2109465ノート

反応式

HRID 2109465 の反応式
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Br:19][C:20]1([Si](C)(C)C)[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[O:22][CH2:21]1>O1CCCC1>[Br:19][C:20]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[O:22][CH:21]=1

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 69053979HCID 69053979、化合物

生成物 1

HCID 576342462-(4-Bromofuran-2-yl)pyridine収率 80.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

Tetra-n-butylammonium fluoride (1M in tetrahydrofuran, 25.1 mL, 25.11 mmol) was added to a solution of 3-bromo-5-(2-pyridyl)-3-(trimethylsilyl)furan (4.96 g, 16.74 mmol) in tetrahydrofuran (50 mL). The reaction mixture was heated at 70° C. (bath temperature) for six hours. The reaction mixture was evaporated, and the residue was purified by flash chromatography using hexane as the eluant to give the sub-title compound as a pale brown solid (3.02 g), m/z 224, 226 (MH+).

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-5659b7f3f12649d9bc3bd7bf643c97f9
出典データセット
uspto-grants-2009_04
特許番号
US07514567B2

反応ノート

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