化工社化工社 化学情報印刷レポート · 研究参考用
Cesium carbonate → 4-[2-(2-Nitrophenoxy)ethyl]morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 1-Morpholinoethanol | HCID 3029376 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[2-(2-Nitrophenoxy)ethyl]morpholine | HCID 867361 | — |
反応手順
As in Example 1 of WO 00/59883, 14.11 g (100 mmol) of 2-fluoronitrobenzene, 14.45 g (100 mmol) of morpholinoethanol, 35.8 g (100 mmol) of cesium carbonate and 100 mL of dimethylformamide were allowed to agitate at room temperature for 7 days. The mixture was then filtered, the dimethylformamide was removed in a rotary evaporator, and the residue was distilled in a bulb tube still at 4 mbar and a furnace temperature of 160 to 170° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07517367B2 |
| 出典データセット | uspto-grants-2009_04 |
| ORD ID | ord-9e10c9e77376474987ad0d0b966fbb38 |
| 出典メモ | uspto-grants-2009_04 |