反应详情

As in Example 1 of WO 00/59883, 14.11 g (100 mmol) of 2-fluoronitrobenzene, 14.45 g (100 mmol) of morpholinoethanol, 35.8 g (100 mmol) of cesium carbonate and 100 mL of dimethylformamide were allowed to agitate at room temperature for 7 days. The mixture was then filtered, the dimethylformamide was removed in a rotary evaporator, and the residue was distilled in a bulb tube still at 4 mbar and a furnace temperature of 160 to 170° C.

1. filtrationThe mixture was then filtered
2. customthe dimethylformamide was removed in a rotary evaporator
3. distillationthe residue was distilled in a bulb tube still at 4 mbar
4. customa furnace temperature of 160 to 170° C.