4-Methyl-4-[2-(2-nitrophenoxy)ethyl]morpholin-4-ium methylsulfate → 4-[2-(2-Aminophenoxy)ethyl]-4-methylmorpholin-4-ium methylsulfate

反応式

[CH3:1][O:2][S:3]([O-:6])(=[O:5])=[O:4].[CH3:7][N+:8]1([CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N+:23]([O-])=O)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[H][H]>C(O)C.[Pd]>[CH3:1][O:2][S:3]([O-:6])(=[O:5])=[O:4].[NH2:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[O:16][CH2:15][CH2:14][N+:8]1([CH3:7])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1

参加物

実験手順

2.08 g (5.5 mmol) of the compound from Step 5.2 was dissolved in 80 mL of ethanol and hydrogenated in the presence of 0.25 g of Pd/C (10%) under 9 bar of hydrogen pressure. After 2 hours, the catalyst was filtered off and the filtrate was evaporated to dryness. This gave 1.9 g (99% of the theoretical) of a colorless oil which was subjected to further reaction without additional purification.