1,2-Dimethoxyethane → [2-(4-Methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine

HRID 2110634ノート

反応式

HRID 2110634 の反応式
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:3]=1.[N:21]1[C:30]2[C:25](=[CH:26][C:27](B(O)O)=[CH:28][CH:29]=2)[CH:24]=[CH:23][CH:22]=1.COCCOC>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([CH2:12][CH2:11][NH:10][C:4]2[CH:3]=[C:2]([C:27]3[CH:26]=[C:25]4[C:30](=[CH:29][CH:28]=3)[N:21]=[CH:22][CH:23]=[CH:24]4)[N:7]=[C:6]([O:8][CH3:9])[N:5]=2)=[CH:14][CH:15]=1

参加物

6

反応物 3

HCID 80711,2-DimethoxyethaneHCID 4192671Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride)2 回HCID 57636025(6-Chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-methoxyphenyl)-ethyl]amine2 回

生成物 1

HCID 11523888[2-(4-Methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine収率 71%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 962Water溶媒

実験手順

A mixture of (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-methoxy-phenyl)-ethyl]-amine (150 mg, 0.51 mmol, Intermediate (8) prepared as described in Example 2 step 1), quinoline-6-boronic acid [176 mg, 1.02 mmol, Intermediate (22)], Cs2CO3 (590 mg, 1.81 mmol) tetrakis(triphenylphosphine)palladium (0) (59 mg, 0.051 mmol), ethylene glycol dimethyl ether (4 mL) and water (1 mL) is placed in a microwave tube, sealed and evacuated and flushed with argon three times and irradiated in a microwave oven at 140° C. for 10 minutes. The reaction mixture is partitioned between EtOAc and water. The organic phase is separated, washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated. The residual solid is subjected to flash column chromatography on silica gel eluting with a mixture of EtOAc and heptane. The material is recrystallized from MeOH to afford [2-(4-methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine [140 mg, 71%, Example 10(a)] LCMS: RT=5.97 minutes, MS: 387 (M+H). IC50=0.6 nM

後処理

  1. customis placed in a microwave tube
  2. customsealed
  3. customevacuated
  4. customflushed with argon three times
  5. customirradiated in a microwave oven at 140° C. for 10 minutes
  6. customThe reaction mixture is partitioned between EtOAc and water
  7. customThe organic phase is separated
  8. washwashed with saturated sodium bicarbonate solution
  9. dry with materialdried over magnesium sulfate
  10. customevaporated
  11. additionThe residual solid is subjected to flash column chromatography on silica gel eluting with a mixture of EtOAc and heptane
  12. customThe material is recrystallized from MeOH

出典と根拠

ORDレコード
ord-bd5d682a3ac04438b6b97c9fc41e8418
出典データセット
uspto-grants-2009_04
特許番号
US07517889B2

反応ノート

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