HCID 57637127、化合物 → 5-(1-Methylethyl)-2-oxazoleethanamine
反応式
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[O:14][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:16][N:17]=1)C1C=CC=CC=1>CO.[Pd]>[CH:18]([C:15]1[O:14][C:13]([CH2:12][CH2:11][NH2:10])=[N:17][CH:16]=1)([CH3:20])[CH3:19]参加物
4
実験手順
6.50 g (22.54 mmol) benzyl[2-(5-isopropyl-oxazol-2-yl)-ethyl]-carbamate are placed in 130 ml of methanol, 3.50 g palladium/charcoal 10% are added, then the mixture is hydrogenated for 5 hours at ambient temperature under a pressure of 14 psi. Then the catalyst is removed by suction filtering, the solution is evaporated down. The residue is extracted with dichloromethane and potassium carbonate solution, the organic phase is dried and evaporated to dryness.
後処理
- customThen the catalyst is removed by suction
- filtrationfiltering
- customthe solution is evaporated down
- extractionThe residue is extracted with dichloromethane and potassium carbonate solution
- customthe organic phase is dried
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-20087eebbdda48429532c38e53e5bb2d
- 出典データセット
- uspto-grants-2009_04
- 特許番号
- US07517995B2
反応ノート
読み込み中…