Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

HRID 2110935ノート

反応式

HRID 2110935 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[O:11][C:12]([CH:15]([CH3:17])[CH3:16])=[N:13][N:14]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:15]([C:12]1[O:11][C:10]([CH2:9][CH2:8][NH2:7])=[N:14][N:13]=1)([CH3:17])[CH3:16]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57637115Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate

生成物 1

HCID 242544832-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4.00 g (15.67 mmol) tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

後処理

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-3cd64995c32240518fbf2960fd30cdf7
出典データセット
uspto-grants-2009_04
特許番号
US07517995B2

反応ノート

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