Trifluoroacetic acid → 1-(3-Phenyl-1,2-oxazol-5-yl)methanamine
反応式
FC(F)(F)C(O)=O.C(OC([NH:15][CH2:16][C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]=1)=O)(C)(C)C>C(Cl)Cl>[NH2:15][CH2:16][C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:18]=1参加物
4
実験手順
Trifluoroacetic acid (1.7 ml, 2.6 mmol) was added dropwise to a solution of 5-(tert-butoxycarbonylaminomethyl)-3-phenylisoxazole (Method 43; 473 mg, 1.73 mmol) in DCM (8 ml) cooled in an ice bath. The mixture was warmed to ambient temperature and stirred for 18 hours and the volatiles removed by evaporation. The residue was triturated with ether to give the title compound (427 mg, 86%). NMR (DMSO) 4.33 (s, 2H), 7.1 (s, 1H), 7.5 (m, 3H), 7.8 (m, 2H), 8.6 (br s, 3H).
後処理
- temperaturecooled in an ice bath
- customthe volatiles removed by evaporation
- customThe residue was triturated with ether
出典と根拠
- ORDレコード
- ord-ca4fd63d70514e33a8f4947a3b8d19a2
- 出典データセット
- uspto-grants-2009_04
- 特許番号
- US07521453B2
反応ノート
読み込み中…