Sodium Azide → 3-(Azidomethyl)-5-methyl-1,2-oxazole

HRID 2111679ノート

反応式

HRID 2111679 の反応式
Cl[CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[N-:9]=[N+:10]=[N-:11].[Na+]>CN(C=O)C.O>[N:9]([CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1)=[N+:10]=[N-:11]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 27357633-(Chloromethyl)-5-methyl-1,2-oxazole

生成物 1

HCID 234409373-(Azidomethyl)-5-methyl-1,2-oxazole収率 73.7%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

3-Chloromethyl-5-methylisoxazole (500 mg, 3.8 mmol) and sodium azide (494 mg, 7.6 mmol) were heated in DMF (10 ml) at 60° C. for 6 hours. The reaction mixture was diluted with water then extracted with EtOAc. The organic extracts were dried (MgSO4) and the volatiles removed by evaporation to give the title compound (387 mg, 73%) as an oil. NMR (DMSO): 2.40 (s, 3H), 4.48 (s, 2H), 6.28 (s, 1H).

後処理

  1. extractionthen extracted with EtOAc
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. customthe volatiles removed by evaporation

出典と根拠

ORDレコード
ord-54ceae5d828b4fef9058789fa5954f32
出典データセット
uspto-grants-2009_04
特許番号
US07521453B2

反応ノート

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