3-(Trifluoromethyl)phenyl isocyanate → HCID 135500083、化合物

HRID 2111965ノート

反応式

HRID 2111965 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:13][C:12](=[O:14])[O:11][N:10]=1.[F:15][C:16]([F:27])([F:26])[C:17]1[CH:18]=[C:19]([N:23]=[C:24]=[O:25])[CH:20]=[CH:21][CH:22]=1>C1COCC1>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[NH:13][C:12](=[O:14])[O:11][N:10]=2)=[C:2]([NH:1][C:24]([NH:23][C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([C:16]([F:15])([F:26])[F:27])[CH:18]=2)=[O:25])[CH:7]=1

参加物

4

反応物 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 1360346823-(2-Amino-4-chlorophenyl)-1,2,4-oxadiazol-5(2H)-one

生成物 1

HCID 135500083HCID 135500083、化合物収率 63%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-(2-Amino-4-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one (400 mg, 1.92 mmol) was dissolved in 20 ml dry THF and 3-trifluoromethyl-phenyl-isocyanate (450 mg, 2.40 mmol) was added and the reaction stirred for 16 hours. The solvent was reduced under vacuum and the product recrystallised from ethyl acetate and heptane to yield 480 mg (63%) of off-white crystalline solid (m.p. 246-248; decomposition).

後処理

  1. customthe product recrystallised from ethyl acetate and heptane

出典と根拠

ORDレコード
ord-06d71198e0ec4e3da5527ee67b1bc718
出典データセット
uspto-grants-2009_04
特許番号
US07521480B2

反応ノート

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