Water → HCID 178487895、化合物

HRID 2112101ノート

反応式

HRID 2112101 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][C:18](O)=[O:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][CH2:18][OH:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 962WaterHCID 178487908HCID 178487908、化合物

生成物 1

HCID 178487895HCID 178487895、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

1.45 g (5.23 mmol) [2-(3-methoxy-4-nitro-phenyl)-1H-imidazol-4-yl]-acetic acid are dissolved in 36 ml THF and cooled to 0° C. and combined with 10 ml (18 mmol) borane-THF complex (1.8 mol/V). After 1 h the mixture is heated to 20° C. and stirred for 16 h. Water is added until the development of gas has ended. Then the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic phases are combined, dried and freed from the solvent in vacuo.

後処理

  1. temperatureAfter 1 h the mixture is heated to 20° C.
  2. extractionThen the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-756862ec6c424e9dab147694a5d8f477
出典データセット
uspto-grants-2009_04
特許番号
US07521457B2

反応ノート

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