3,3-Dimethyl-7-nitro-2,3-dihydro-isoindol-1-one → 3,3-Dimethyl-7-amino-2,3-dihydro-isoindol-1-one
反応式
[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[C:6]([N+:11]([O-])=O)[CH:7]=[CH:8][CH:9]=2)[C:4](=[O:14])[NH:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:15])[C:10]2[C:5](=[C:6]([NH2:11])[CH:7]=[CH:8][CH:9]=2)[C:4](=[O:14])[NH:3]1参加物
4
実験手順
67 mg (0.325 mmol) 3,3-dimethyl-7-nitro-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 4 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
後処理
- filtrationThen the catalyst is filtered off
出典と根拠
- ORDレコード
- ord-5abc06f3a19d4a38a44e89590cf20fc1
- 出典データセット
- uspto-grants-2009_04
- 特許番号
- US07521457B2
反応ノート
読み込み中…