7-Dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one → 7-Amino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

HRID 2112110ノート

反応式

HRID 2112110 の反応式
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22])C1C=CC=CC=1>CO.[Pd]>[NH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22]

参加物

4

反応物 1

HCID 866061867-Dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

生成物 1

HCID 576401547-Amino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

75 mg (0.188 mmol) 7-dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 5 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

後処理

  1. filtrationThen the catalyst is filtered off

出典と根拠

ORDレコード
ord-a2c4dccc7c114ef3a319530cc007410d
出典データセット
uspto-grants-2009_04
特許番号
US07521457B2

反応ノート

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