Sodium Hydroxide → 2-Amino-5-fluorobenzenesulfonamide

HRID 2112561ノート

反応式

HRID 2112561 の反応式
[F:1][C:2]1[CH:14]=[CH:13][C:5]2[NH:6]C(=O)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:6][C:5]1[CH:13]=[CH:14][C:2]([F:1])=[CH:3][C:4]=1[S:9]([NH2:8])(=[O:11])=[O:10]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 110960067-Fluoro-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

生成物 1

HCID 224818252-Amino-5-fluorobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
130 °C

実験手順

After suspending 7-fluoro-2H,4H-benzo[e]1,2,4-thiadiazine-1,1,3-trione (3.00 g, 13.9 mmol) in 50% sulfuric acid (90 mL), the mixture was stirred at 130° C. for 1 hour. The reaction mixture was cooled in an ice bath while adding 40% aqueous sodium hydroxide for neutralization. The aqueous solution was concentrated under reduced pressure to 200 mL, and the precipitate was filtered out. It was then suspended in ethyl acetate (100 mL), and the insoluble portion was filtered out. The filtrate was concentrated under reduced pressure and dried to obtain 2-amino-5-fluorobenzenesulfonamide.

後処理

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. concentrationThe aqueous solution was concentrated under reduced pressure to 200 mL
  3. filtrationthe precipitate was filtered out
  4. filtrationthe insoluble portion was filtered out
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customdried

出典と根拠

ORDレコード
ord-56b4425951284b84b419c32c38a91b0f
出典データセット
uspto-grants-2009_04
特許番号
US07524841B2

反応ノート

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