Sodium Bicarbonate → 4-Acetamido-3-hydroxyphenyl acetate

HRID 2112740ノート

反応式

HRID 2112740 の反応式
[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=[O:18].O.C([O-])(O)=O.[Na+]>C1COCC1>[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][C:10](=[O:18])[CH3:12])=[C:7]([OH:11])[CH:6]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 156622632-Methylbenzo[d]oxazol-6-yl acetateHCID 22392675Trifluoroacetic acid water

生成物 1

HCID 688181524-Acetamido-3-hydroxyphenyl acetate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-methyl-1,3-benzoxazol-6-yl acetate (5.05 g, 28.8 mmol) in THF (100 mL) a mixture of trifluoroacetic acid/water (4 mL/10 mL) was added. The reaction mixture was stirred at room temperature for 16 hours, saturated aqueous NaHCO3 (150 mL) was added. The mixture was extracted with ethyl acetate, dried over Na2SO4, filtered and concentrated in vacuo to give sub-title compound (4.0 g) as a crude product.

後処理

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-ad3ad19dac9d46f0ba6b56b1395b4f67
出典データセット
uspto-grants-2009_04
特許番号
US07524856B2

反応ノート

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