Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2113634ノート

反応式

HRID 2113634 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

生成物 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2.2 1.14 g of (2-chloro-6-methylpyridin-4-yl)methanol are initially introduced in 50 ml of toluene, and 1.05 ml of thionyl chloride are slowly added dropwise with ice cooling. The mixture is boiled under reflux overnight. After cooling, the solvent is removed, giving 2-chloro-4-chloromethyl-6-methylpyridine as brown oil (1.1 g).

後処理

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent is removed

出典と根拠

ORDレコード
ord-e624334278f045eebad3125f2b59d0fb
出典データセット
uspto-grants-2008_10
特許番号
US07432282B2

反応ノート

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