Lithium Hydroxide → 3-(5-p-Tolyl-isoxazol-3-yl)-benzoic acid

HRID 2113908ノート

反応式

HRID 2113908 の反応式
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=3)[O:12][N:11]=2)[CH:5]=1.[OH-].[Li+]>O1CCOCC1>[C:18]1([CH3:21])[CH:17]=[CH:16][C:15]([C:13]2[O:12][N:11]=[C:10]([C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:22])=[O:2])[CH:14]=2)=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 57907091Methyl 3-(5-p-tolylisoxazol-3-yl)benzoate

生成物 1

HCID 579071533-(5-p-Tolyl-isoxazol-3-yl)-benzoic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

In a 25 ml round flask, 330 mg (1.13 mmol) of 3-[5-p-tolyl-isoxazol-3-yl]-benzoic acid methyl ester is dissolved in 10 ml of dioxane and subsequently 1.69 ml of aqueous lithium hydroxide (1M, 1.69 mmol, 1.5 eq.) are added and the resulting solution stirred for 20 h at room temperature. Then, the dioxane is removed in vacuo, 10 ml of water are added and the pH adjusted to 2 with hydrochloric acid (1M). The precipitate is filtered and dried to yield the title compound as a white solid. Mass spectrum: m/z (M−H)+: 278.2

後処理

  1. customThen, the dioxane is removed in vacuo, 10 ml of water
  2. additionare added
  3. filtrationThe precipitate is filtered
  4. customdried

出典と根拠

ORDレコード
ord-591d636e6d83455a96a5761dba17be02
出典データセット
uspto-grants-2008_10
特許番号
US07432293B2

反応ノート

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