Hydrochloric Acid → 4-(1-Naphthyl)-4-oxobutanoic acid

HRID 2114

反応式

HRID 2114 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[C:11]1(=[O:17])[O:16][C:14](=[O:15])[CH2:13][CH2:12]1.[Cl-].[Cl-].[Cl-].[Al+3].Cl>[N+](C1C=CC=CC=1)([O-])=O>[C:9]1([C:11]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:17])[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=2)[CH:6]=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 931NaphthaleneHCID 7922Succinic anhydrideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 2777864-(1-Naphthyl)-4-oxobutanoic acid

試薬・触媒・溶媒 1

HCID 7416Nitrobenzene溶媒

実験手順

A mixture of naphthalene (40 g) and succinic anhydride (20 g) was added to a well stirred suspension of aluminum trichloride (55 g) in nitrobenzene (140 ml). The resulting mixture was stirred overnight at room temperature. The mixture was then poured slowly onto ice-water (600 g) and acidified with 6N-hydrochloric acid. The crude acid was filtered, washed with water until washings were neutral and recrystallized from ethanol yielding the product (m.p. 170°-172° C.).

後処理

  1. additionwas added to a well
  2. stirringThe resulting mixture was stirred overnight at room temperature
  3. additionThe mixture was then poured slowly onto ice-water (600 g)
  4. filtrationThe crude acid was filtered
  5. washwashed with water until washings
  6. customrecrystallized from ethanol yielding the product (m.p. 170°-172° C.)

出典と根拠

ORDレコード
ord-9cda8deef8464fdbb84bc3f44d4fe1f5
出典データセット
uspto-grants-1998_03
特許番号
US05728698

関連ノート

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