Pyrazole → 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid {2-[4-(4,5-dihydro-1h-imidazol-2-yl)-phenyl]ethyl}amide

HRID 2114313ノート

反応式

HRID 2114313 の反応式
[NH:1]1[CH:5]=[CH:4]C=N1.[CH3:6][N:7]([C@@H](C1C=CC=CC=1)C)[C:8]([C:10]1[C:14]([Br:15])=[C:13]([NH:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])[NH:12][N:11]=1)=[O:9].Cl[C:35]1C=CC=CC=1C(Cl)=O.NC[CH2:46][C:47]1[CH:54]=[CH:53][C:50]([C:51]#[N:52])=[CH:49][CH:48]=1>>[NH:1]1[CH2:5][CH2:4][N:52]=[C:51]1[C:50]1[CH:49]=[CH:48][C:47]([CH2:46][CH2:6][NH:7][C:8]([C:10]2[C:14]([Br:15])=[C:13]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])[N:12]([CH3:35])[N:11]=2)=[O:9])=[CH:54][CH:53]=1

参加物

5

反応物 4

HCID 1048PyrazoleHCID 691102-Chlorobenzoyl chlorideHCID 219125254-(2-Aminoethyl)benzonitrileHCID 178461679HCID 178461679、化合物

生成物 1

HCID 597735614-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid {2-[4-(4,5-dihydro-1h-imidazol-2-yl)-phenyl]ethyl}amide

実験手順

The pyrazole acid, prepared by coupling methyl ester 85 (Procedure 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Procedure 8, was coupled to amine 169 (Procedure 34) using the method of Procedure 10. Formation of the amidine using the method of Procedure 33.

後処理

  1. customfollowed by hydrolysis and bromination

出典と根拠

ORDレコード
ord-e69be65630d14143b64dcbb7b8392af9
出典データセット
uspto-grants-2008_10
特許番号
US07432379B2

反応ノート

読み込み中…