4-Methoxy-5-methyl-2-nitrophenol → 2-Amino-4-methoxy-5-methylphenol

HRID 2114356ノート

反応式

HRID 2114356 の反応式
[CH3:1][C:2]1[C:3]([O:12][CH3:13])=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([OH:8])[CH:7]=1>CCOC(C)=O.[Pd]>[NH2:9][C:5]1[CH:4]=[C:3]([O:12][CH3:13])[C:2]([CH3:1])=[CH:7][C:6]=1[OH:8]

参加物

4

反応物 1

HCID 574186644-Methoxy-5-methyl-2-nitrophenol

生成物 1

HCID 130767582-Amino-4-methoxy-5-methylphenol収率 98%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

5-Methyl-4-(methyloxy)-2-nitrophenol (3.65 g, 20 mmol) was dissolved in EtOAc (100 mL) and 200 mg of 5% Pd/C was added. The reaction vessel was evacuated and filled with N2. This process was repeated twice then filled with H2 at 1 atm, and stirred for 16 h. The mixture was filtered through a pad of celite, washed with EtOAc, and the solvent was removed via rotovap to give the title compound (3.0 g, 98%) as a white solid. MS (ES) m/e 154 [M+H]+.

後処理

  1. customThe reaction vessel was evacuated
  2. additionfilled with N2
  3. additionThis process was repeated twice then filled with H2 at 1 atm
  4. filtrationThe mixture was filtered through a pad of celite
  5. washwashed with EtOAc
  6. customthe solvent was removed via rotovap

出典と根拠

ORDレコード
ord-0801897b26b04a3eacc143492504e88a
出典データセット
uspto-grants-2008_10
特許番号
US07432258B2

反応ノート

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