Nitric Acid → 7-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

HRID 2114865ノート

反応式

HRID 2114865 の反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[CH2:7]2.[N+:13]([O-])([OH:15])=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]([N+:13]([O-:15])=[O:14])[CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[CH2:7]2

参加物

3

反応物 2

HCID 944Nitric AcidHCID 119516747-Fluoro-1-methylindolin-2-one

生成物 1

HCID 119516757-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

実験手順

7-Fluoro-1-methyl-1,3-dihydro-indol-2-one (7, 2.00 g, 0.0119 mol) is added portion wise to 70% nitric acid (10 ml) at −10° C. After the addition is complete, the reaction is allowed to warm to room temperature and then stirred for 20 hours. The mixture is diluted with ice water and the resulting precipitate filtered, washed with water, and dried under vacuum to give the title compound as a solid. HPLC r.t. 4.40 min.

後処理

  1. additionAfter the addition
  2. filtrationthe resulting precipitate filtered
  3. washwashed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-604b3d1dd6cc41a0b4d1970a95cd1b47
出典データセット
uspto-grants-2008_10
特許番号
US07435751B2

反応ノート

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