Hydrochloric Acid → 7-Fluoro-1-isopropyl-5-nitro-1,3-dihydro-indol-2-one
反応式
F[C:2]1[C:7]([F:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=O.[CH:16]([NH2:19])([CH3:18])[CH3:17].Cl>CS(C)=O>[F:8][C:7]1[CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[CH:4]=[C:3]2[C:2]=1[N:19]([CH:16]([CH3:18])[CH3:17])[C:13](=[O:15])[CH2:12]2参加物
5
反応条件
- 温度
- 45 °C
実験手順
Crude (2,3-difluoro-5-nitrophenyl)acetic acid (16, 1.00 g, 0.00461 mol) and isopropylamine (6 eq., 2.35 ml, 0.0276 mol) are mixed in DMSO (5 ml) and stirred at 45° C. for 1 hour. 2N Hydrochloric acid (20 ml) is added in one portion and the mixture stirred at room temperature for 1 hour. The resulting precipitate is filtered, washed with water and ether, and dried under vacuum (0.39 g, 35%); HPLC r.t. 5.31 min.
後処理
- stirringthe mixture stirred at room temperature for 1 hour
- filtrationThe resulting precipitate is filtered
- washwashed with water and ether
- customdried under vacuum (0.39 g, 35%)
出典と根拠
- ORDレコード
- ord-3ee7ece6e31946d496002b2eb4f61688
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07435751B2
反応ノート
読み込み中…