Hydrazine hydrate (1:1) → 1-Ethyl-7-fluoro-1,3-dihydro-indol-2-one

HRID 2114878ノート

反応式

HRID 2114878 の反応式
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[C:5](=O)[C:4]1=[O:14])[CH3:2].O.NN>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:12])[CH2:5][C:4]1=[O:14])[CH3:2]

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 692740961-Ethyl-7-fluoroindoline-2,3-dione

生成物 1

HCID 692741661-Ethyl-7-fluoro-1,3-dihydro-indol-2-one

実験手順

1-Ethyl-7-fluoro-1H-indole-2,3-dione (3.60 g, 18.6 mmol) is heated with neat hydrazine hydrate (15 ml) at 130° C. for 60 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as an orange solid. HPLC r.t. 4.60 min; MS for C10H10FNO m/z 198.1 (M+H)+.

後処理

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-874f48d9ff134c66b85b11ac059663fc
出典データセット
uspto-grants-2008_10
特許番号
US07435751B2

反応ノート

読み込み中…