7-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione → 7-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

HRID 2114885ノート

反応式

HRID 2114885 の反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[C:7]2=O>O.NN>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2

参加物

3

反応物 1

HCID 739475787-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione

生成物 1

HCID 739475797-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

試薬・触媒・溶媒 1

HCID 24654Hydrazine hydrate (1:1)溶媒

実験手順

7-Fluoro-1-(2-fluoro-ethyl)-1H-indole-2,3-dione (1.04 g, 4.92 mmol) is heated with neat hydrazine hydrate (10 ml) at 130° C. for 20 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as a brown solid. HPLC r.t. 4.36 min; MS for C10H9F2NO m/z 198.1 (M+H)+.

後処理

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-5bfc516fcc2c46f9bdc26ad529cf186c
出典データセット
uspto-grants-2008_10
特許番号
US07435751B2

反応ノート

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