Nitric Acid → 7-Fluoro-1-(2-fluoro-ethyl)-5-nitro-1,3-dihydro-indol-2-one

HRID 2114886ノート

反応式

HRID 2114886 の反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2.[N+:15]([O-])([OH:17])=[O:16]>>[F:1][C:2]1[CH:3]=[C:4]([N+:15]([O-:17])=[O:16])[CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2

参加物

3

反応物 2

HCID 944Nitric AcidHCID 739475797-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

生成物 1

HCID 739475807-Fluoro-1-(2-fluoro-ethyl)-5-nitro-1,3-dihydro-indol-2-one

実験手順

7-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one (0.880 g, 0.0119 mol) is added portionwise to 70% nitric acid (8 ml) at −10° C. After the addition is complete, the reaction is allowed to warm to room temperature and then stirred for 24 hours. The mixture is diluted with ice water and the resulting precipitate filtered, washed with water, and dried under vacuum to give the title compound as a light brown solid. HPLC r.t. 4.65 min; MS for C10H8F2N2O3 m/z 243.3 (M+H)+.

後処理

  1. additionAfter the addition
  2. filtrationthe resulting precipitate filtered
  3. washwashed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-8a5c39e54d3a42f1a067b722122fde5d
出典データセット
uspto-grants-2008_10
特許番号
US07435751B2

反応ノート

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