Ammonium Chloride → HCID 69274126、化合物

HRID 2114898ノート

反応式

HRID 2114898 の反応式
[CH:1]1([N:4]2[C:12]3[C:7](=[CH:8][C:9]([N+:14]([O-])=O)=[CH:10][C:11]=3[F:13])[CH2:6][C:5]2=[O:17])[CH2:3][CH2:2]1.[Cl-].[NH4+]>C(O)C.O.ClCCl.[Fe]>[NH2:14][C:9]1[CH:8]=[C:7]2[C:12](=[C:11]([F:13])[CH:10]=1)[N:4]([CH:1]1[CH2:2][CH2:3]1)[C:5](=[O:17])[CH2:6]2

参加物

7

反応物 2

HCID 25517Ammonium ChlorideHCID 692754101-Cyclopropyl-7-fluoro-5-nitro-1,3-dihydro-indol-2-one

生成物 1

HCID 69274126HCID 69274126、化合物

試薬・触媒・溶媒 4

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

Iron powder (0.994 g, 17.8 mmol) is added in small portions to 1-cyclopropyl-7-fluoro-5-nitro-1,3-dihydro-indol-2-one (1.05 g, 4.44 mmol) and ammonium chloride (2.32 g, 44.5 mmol) in ethanol (50 ml) and water (25 ml) at 90° C. The reaction mixture is stirred vigorously and heated for 60 min, cooled to room temperature, and diluted with dichloromethane (250 ml). The mixture is filtered through celite, the organic layer separated and washed with water and brine, dried over sodium sulfate and evaporated to give the title compound as a yellowish-brown solid. HPLC r.t. 2.62 min; MS for C11H11FN2O m/z 207.2 (M+H)+.

後処理

  1. temperatureheated for 60 min
  2. filtrationThe mixture is filtered through celite
  3. customthe organic layer separated
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-e044301ff39f48fe99e0d6e529cb2e36
出典データセット
uspto-grants-2008_10
特許番号
US07435751B2

反応ノート

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