Ammonium Acetate → 5-Amino-cyclooctanecarbonitrile
反応式
O=[C:2]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]#[N:11])[CH2:5][CH2:4][CH2:3]1.C([O-])(=O)C.[NH4+].C([BH3-])#[N:18].[Na+]>CO>[NH2:18][CH:2]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10]#[N:11])[CH2:5][CH2:4][CH2:3]1参加物
5
実験手順
The product of Example 10B (0.259 g, 1.71 mmol), ammonium acetate (1.32 g, 17.14 mmol), and sodium cyanoborohydride (0.43 g, 6.84 mmol) was stirred in methanol (8 mL) for twelve hours. The solvent was evaporated and the residue was partitioned with dichloromethane and water. The organic phase was washed with NaHCO3 solution and brine, dried (Na2SO4), filtered, and evaporated. The crude title compound was used in the following step without further purification.
後処理
- customThe solvent was evaporated
- customthe residue was partitioned with dichloromethane and water
- washThe organic phase was washed with NaHCO3 solution and brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customevaporated
- customThe crude title compound was used in the following step without further purification
出典と根拠
- ORDレコード
- ord-ca33800ebf414009a93d5b541a48443e
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07435833B2
反応ノート
読み込み中…