4-Ethylphenyl-3-hydroxypyridin-2-yl-methanol → HCID 23103632、化合物
反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][N:12]=2)O)=[CH:5][CH:4]=1)[CH3:2]>[OH-].[OH-].[Pd+2].C(O)(=O)C>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:11]2[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:5][CH:4]=1)[CH3:2]参加物
4
実験手順
A mixture of 4-ethylphenyl-3-hydroxypyridin-2-yl-methanol (0.60 g, 2.62 mmol), 20% palladium hydroxide/carbon (300 mg) and acetic acid (8 mL) was stirred under a hydrogen atmosphere for 76 hours. After filtration to remove the insoluble materials, the filtrate was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to give 2-(4-ethylbenzyl)-3-hydroxypyridine (0.46 g, 82%) as a colorless powder.
後処理
- filtrationAfter filtration
- customto remove the insoluble materials
- customthe filtrate was purified by silica gel column chromatography (hexane:ethyl acetate=1:1)
出典と根拠
- ORDレコード
- ord-ebe981b869ec48d2b12ca90ec855386d
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07439232B2
反応ノート
読み込み中…