Potassium Carbonate → 4-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-methylpropyl)-1,3-thiazol-2-yl]thio}-2H-chromen-2-one

HRID 2116646

反応式

HRID 2116646 の反応式
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[SH:20][C:21]1[S:22][C:23]([C:26]([OH:30])([CH2:28][CH3:29])[CH3:27])=[CH:24][N:25]=1.C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([S:20][C:21]4[S:22][C:23]([C:26]([OH:30])([CH3:27])[CH2:28][CH3:29])=[CH:24][N:25]=4)=[CH:3][CH:4]=3)[O:9][C:8](=[O:12])[CH:7]=2)=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 233702437-Bromo-4-(4-fluorophenyl)-chromen-2-oneHCID 178450294HCID 178450294、化合物

生成物 1

HCID 598148544-(4-fluorophenyl)-7-{[5-(1-hydroxy-1-methylpropyl)-1,3-thiazol-2-yl]thio}-2H-chromen-2-one

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

Employing the procedure described in Example 1, Step 3, using 7-bromo-4-(4-fluorophenyl)-2H-chromen-2-one, 2-(2-mercapto-1,3-thiazole-5-yl)butan-2-ol and K2CO3 in NMP, the title compound was obtained. 1H NMR (400 MHz, acetone-d6): δ 7.72 (s, 1H), 7.63-7.68 (m, 2H), 7.51 (d, 1H), 7.43 (d, 1H), 7.33-7.41 (m, 3H), 6.38 (s, 1H), 1.93-1.80 (m, 2H), 1.61 (s, 3H), 0.90 (t, 3H).

出典と根拠

ORDレコード
ord-b6fe53f822ea4d28a1277ff6342d4587
出典データセット
uspto-grants-2008_10
特許番号
US07439260B2

関連ノート

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