Diethyl (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonate → HCID 9813750、化合物
反応式
C([O:3][C:4](=[O:22])[CH:5]([CH2:11][C:12]1[C:13]([CH2:20][OH:21])=[C:14]([OH:19])[C:15]([CH3:18])=[N:16][CH:17]=1)[C:6]([O:8]CC)=[O:7])C>[OH-].[Na+].C(O)C>[CH3:18][C:15]1[C:14]([OH:19])=[C:13]([CH2:20][OH:21])[C:12]([CH2:11][CH:5]([C:6]([OH:8])=[O:7])[C:4]([OH:22])=[O:3])=[CH:17][N:16]=1参加物
4
実験手順
The product of Example 25, of structure XXIX (620 mg, 2.0 mmol) was dissolved in aqueous NaOH (2 M, 4 mL) and stirred at room temperature for 1 hour. The reaction was quenched by adding 6 N HCl to give pH 4 to 5. The solution was diluted with 95% ethanol, separated from the precipitated salts and evaporated to give 540 mg.
後処理
- customThe reaction was quenched
- additionby adding 6 N HCl
- customto give pH 4 to 5
- customseparated from the precipitated salts
- customevaporated
- customto give 540 mg
出典と根拠
- ORDレコード
- ord-9a4e806a99194468a37edcb6e7fd43aa
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07442689B2
反応ノート
読み込み中…