Hexane → 1-Benzothien-7-ylboronic acid
反応式
Br[C:2]1[C:10]2[S:9][CH:8]=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([Li])CCC.CCCCCC.[B:22](OC)([O:25]C)[O:23]C>CCOCC>[S:9]1[C:10]2[C:2]([B:22]([OH:25])[OH:23])=[CH:3][CH:4]=[CH:5][C:6]=2[CH:7]=[CH:8]1参加物
6
反応条件
- 温度
- -10 °C
実験手順
A solution of 7-bromo-1-benzothiophene (19.9 g, 0.094 mol) in absolute ether (200 ml) was treated with a 1.6 M solution of n-butyllithium in hexane (0.14 mol, 88 ml) at −78° C. The solution was stiffed at −78° C. for 10 minutes then treated with trimethyl borate (15 ml, 0.14 mol). The mixture was allowed to warm to −10° C. then quenched with an excess of dilute hydrochloric acid. The organic layer was separated, dried, evaporated, and the residue was recrystallised from aqueous ethanol to yield the title compound (10 g, 60%).
後処理
- customthen quenched with an excess of dilute hydrochloric acid
- customThe organic layer was separated
- customdried
- customevaporated
- customthe residue was recrystallised from aqueous ethanol
出典と根拠
- ORDレコード
- ord-ece564e6cbef422489e0a200676991f5
- 出典データセット
- uspto-grants-2008_10
- 特許番号
- US07442701B2
反応ノート
読み込み中…