Hydrochloric Acid → Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

HRID 2117615

反応式

HRID 2117615 の反応式
[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]#[N:13])[CH:7]=1.[ClH:15]>[Pd].CO>[ClH:15].[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 53396017Methyl 3-(3-cyanophenyl)prop-2-enoate

生成物 1

HCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 3-(3-cyano-phenyl)-acrylic acid methyl ester of Step B (1.37 g, 7.32 mmol), 10% palladium on carbon (1.0 g), and HCl (4N in dioxane, 3 mL) in MeOH (50 mL) was hydrogenated on a Parr shaker at 50 psi for 65 h. The catalyst was removed by filtration through Celite and the solution was concentrated to provide the title compound (1.97 g). 1H NMR (400 MHz, CD3OD) δ 7.35-7.24 (m, 4H), 4.06 (s, 2H), 3.60 (s, 3H), 2.92 (t, 2H), 2.64 (t, 2H).

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe solution was concentrated

出典と根拠

ORDレコード
ord-52363373f5684974981a0b5e4625e536
出典データセット
uspto-grants-2008_10
特許番号
US07442702B2

関連ノート

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