m-Iodobenzenesulphonyl chloride → N2-[(3-Iodophenyl)sulfonyl]glycinamide

HRID 2117672ノート

反応式

HRID 2117672 の反応式
[I:1][C:2]1[CH:3]=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:13][CH2:14][C:15]([NH2:17])=[O:16].C(N(C(C)C)CC)(C)C>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([S:8]([NH:13][CH2:14][C:15]([NH2:17])=[O:16])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 39766m-Iodobenzenesulphonyl chlorideHCID 81531DiisopropylethylamineHCID 2723639Glycinamide hydrochloride

生成物 1

HCID 21895595N2-[(3-Iodophenyl)sulfonyl]glycinamide収率 42.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

(3-Iodophenyl)sulphonyl chloride (0.303 g) was stirred with glycinamide hydrochloride (0.122 g) and diisopropylethylamine (0.3 ml) in DMF (4 ml) at 21° for 24 h. The mixture was evaporated to dryness and applied to a silica Bond Elut Cartridge (10 g). The cartridge was eluted with CH2Cl2, Et2O and EtOAc. This gave the title compound (0.146 g), LCMS RT=2.36 min, ES+ve 341 (MH)+

後処理

  1. customThe mixture was evaporated to dryness
  2. washThe cartridge was eluted with CH2Cl2, Et2O and EtOAc

出典と根拠

ORDレコード
ord-9d1f6383ed86413ebf153c06995ac7a0
出典データセット
uspto-grants-2008_10
特許番号
US07442719B2

反応ノート

読み込み中…