4-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine → HCID 69314355、化合物

HRID 2117759ノート

反応式

HRID 2117759 の反応式
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:5][N:4]=[C:3]1[CH:20]=[C:21]([CH3:23])[CH3:22]>C(O)C.[Pd]>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:8]=2)=[CH:5][N:4]=[C:3]1[CH2:20][CH:21]([CH3:23])[CH3:22]

参加物

4

反応物 1

HCID 693092264-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine

生成物 1

HCID 69314355HCID 69314355、化合物収率 71%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

4-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine (method 110; 400 mg, 1.3 mmol), and 10% Pd on C catalyst (150 mg), in ethanol (50 ml), was hydrogenated at 40 C and 20 bar for 18 hours. The catalyst was removed by filtration and the filter pad washed with ethanol. The solvent was evaporated and the residue triturated with ether and collected by filtration to give the title compound (280 mg, 71%). M/z: 308.

後処理

  1. customThe catalyst was removed by filtration
  2. washthe filter pad washed with ethanol
  3. customThe solvent was evaporated
  4. customthe residue triturated with ether
  5. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-29c1ce49c6e043ca9c89de0e1ce2ea06
出典データセット
uspto-grants-2008_10
特許番号
US07442697B2

反応ノート

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