Pyridine → Ethyl 2-acetamido-1,3-thiazole-4-carboxylate

HRID 2117848ノート

反応式

HRID 2117848 の反応式
Br.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1.N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20]>ClCCl>[C:19]([NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1)(=[O:21])[CH3:20]

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 16495520Ethyl 2-aminothiazole-4-carboxylate hydrobromide

生成物 1

HCID 702548Ethyl 2-acetamido-1,3-thiazole-4-carboxylate収率 88.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To an ice-cold mixture of ethyl 2-amino-1,3-thiazole-4-carboxylate hydrobromide (80 g), pyridine (52.5 g) and dichloromethane (800 ml) was added acetyl chloride (27.3 g) dropwise at 0° C., and the mixture was stirred for 30 minutes at the same temperature. The reaction mixture was washed with water (500 ml), dried over sodium sulfate and concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-(acetylamino)-1,3-thiazole-4-carboxylate (60 g).

後処理

  1. washThe reaction mixture was washed with water (500 ml)
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crystalline residue was collected
  5. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-40cbf9f3112b4c81a9aa7ddc9b4da7c6
出典データセット
uspto-grants-2008_10
特許番号
US07442715B2

反応ノート

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