Hydrazine hydrate (1:1) → 1-(Pyridin-2-yl)piperidine-4-carbohydrazide

HRID 2118008ノート

反応式

HRID 2118008 の反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:8][CH2:7]1)=O)C.O.[NH2:19][NH2:20]>CO>[N:9]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:10][CH2:11][CH:6]([C:4]([NH:19][NH2:20])=[O:3])[CH2:7][CH2:8]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 38156184-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester

生成物 1

HCID 235440481-(Pyridin-2-yl)piperidine-4-carbohydrazide収率 52.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester (1 g, 4.3 mmol)(see reference Farmaco, 1993, 48(10), 1439) was dissolved in methanol (20 ml) containing hydrazine hydrate (620 μl, 20 mmol) and was heated under reflux for 18 hours. The mixture was cooled to room temperature and evaporated under reduced pressure. The solid formed was triturated with propan-2-ol to give the title compound as a white solid (493 mg).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customevaporated under reduced pressure
  4. customThe solid formed
  5. customwas triturated with propan-2-ol

出典と根拠

ORDレコード
ord-bbea2483ae5e46019d518874b8363182
出典データセット
uspto-grants-2008_10
特許番号
US07442795B2

反応ノート

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