Nitric Acid → 1H-Imidazole, 4-methyl-5-nitro-

HRID 2118542ノート

反応式

HRID 2118542 の反応式
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[N+:7]([O-])([OH:9])=[O:8].S(=O)(=O)(O)O>>[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[N+:7]([O-:9])=[O:8]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178418800HCID 178418800、化合物

生成物 1

HCID 862781031H-Imidazole, 4-methyl-5-nitro-収率 41.6%

反応条件

温度
100 °C

実験手順

4-Methylimidazole (10 g, 0.12 moles), was cooled in a flask, and fuming nitric acid (11 ml, 0.24 moles) was added dropwise. This was followed by the addition of sulfuric acid (11 ml). The reaction was then heated with stirring at 100° C. for 21/2 hours. The cooled reaction mixture was then added to 500 ml of ice water, and the precipitate was filtered off. The filtrate was neutralized with ammonium hydroxide, and filtered again. The combined precipitates were then recrystallized from water to give 6.35 g of 4-methyl-5-nitroimidazole.

後処理

  1. temperatureThe reaction was then heated
  2. customThe cooled reaction mixture
  3. filtrationthe precipitate was filtered off
  4. filtrationfiltered again
  5. customThe combined precipitates
  6. customwere then recrystallized from water

出典と根拠

ORDレコード
ord-1047adf5abe64db5a19761ff3104dd6d
出典データセット
uspto-grants-1987_07
特許番号
US04678799

反応ノート

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