Hydrazine hydrate (1:1) → 1-Amino-8-(1-naphthyloxy)octane

HRID 2118659ノート

反応式

HRID 2118659 の反応式
[C:1]1([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]2C(=O)C3=CC=CC=C3C2=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[NH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 13520543N-8-(1-naphthyloxy)octylphthalimide

生成物 1

HCID 135205411-Amino-8-(1-naphthyloxy)octane

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 10.0 g N-[8-(1-naphthyloxy)octyl]phthalimide, prepared as above, and 200 ml of ethanol and 3.2 ml of hydrazine hydrate was refluxed for 18 hours. The solution was evaporated to about 100 ml, and diluted with 200 ml of water, then basified with aqueous potassium hydroxide and extracted with hexane. The extract was washed, dried and evaporated to give the title compound as an oil which was converted to the hydrochloride, mp 90.5°-92°.

後処理

  1. temperaturewas refluxed for 18 hours
  2. customThe solution was evaporated to about 100 ml
  3. additiondiluted with 200 ml of water
  4. extractionextracted with hexane
  5. washThe extract was washed
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-8730f934c84d41ea84f6537e8950a6b8
出典データセット
uspto-grants-1987_07
特許番号
US04680300

反応ノート

読み込み中…