HCID 13633455、化合物 → HCID 13633450、化合物

HRID 2118676ノート

反応式

HRID 2118676 の反応式
[C:1]1([C:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:26]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:12][CH2:13]2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

5

反応物 2

HCID 13633455HCID 13633455、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 13633450HCID 13633450、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 4 g of 1-[2-[4-diphenylmethylene-1-piperidinyl]ethyl]-1,3-dihydro-2(2H)-benzimidazolone in 150 cm3 of methanol is hydrogenated with the aid of a Parr apparatus, at ambient temperature, at a hydrogen pressure of 50 psi, in the presence of 5% palladium on charcoal. When the absorption of hydrogen has ended, the catalyst is filtered off and the filtrate is evaporated down. The product obtained is recrystallized from ethyl acetate. M.p.=195°-196° C.

後処理

  1. customWhen the absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. customthe filtrate is evaporated down
  4. customThe product obtained
  5. customis recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-bffebfb5aeac405ba97867809734a1b0
出典データセット
uspto-grants-1987_07
特許番号
US04680296

反応ノート

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